#USA Timescale announces $15M investment and new enterprise version of TimescaleDB

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It’s a big day for Timescale, makers of the open source time series database, TimescaleDB. The company announced a $15 million investment and a new enterprise version of the product.

The investment is technically an extension of the $12.4 million Series A it raised last January, which it’s referring to as A1. Today’s round is led by Icon Ventures with existing investors Benchmark, NEA and Two Sigma Ventures also participating. With today’s funding, the startup has raised $31 million.

Timescale makes a time series database. That means it can ingest large amounts of data and measure how it changes over time. This comes in handy for a variety of use cases from financial services to smart homes to self-driving cars — or any data-intensive activity  you want to measure over time.

While there are a number of time scale database offerings on the market, Timescale co-founder and CEO Ajay Kulkarni says that what makes his company’s approach unique is that it uses SQL, one of the most popular languages in the world. Timescale wanted to take advantage of that penetration and build its product on top of Postgres, the popular open source SQL database. This gave it an offering that is based on SQL and highly scalable.

Timescale admittedly came late to the market in 2017, but by offering a unique approach and making it open source, it has been able to gain traction quickly. “Despite entering into what is a very crowded database market, we’ve seen quite a bit of community growth because of this message of SQL and scale for time series,” Kulkarni told TechCrunch.

In just over 22 months, the company has over a million downloads and a range of users from older guard companies like Charter, Comcast and Hexagon Mining to more modern companies like Nutanix and and TransferWise.

With a strong base community in place, the company believes that it’s now time to commercialize its offering, and in addition to an open source license, it’s introducing a commercial license.”Up until today, our main business model has been through support and deployment assistance. With this new release, we will be also will have enterprise features that are available with a commercial license,” Kulkarni explained.

The commercial version will offer a more sophisticated automation layer for larger companies with greater scale requirements. It will also provide better lifecycle management, so companies can get rid of older data or move it to cheaper long-term storage to reduce costs. It’s also offering the ability to reorder data in an automated fashion when that’s required, and finally, it’s making it easier to turn the time series data into a series of data points for analytics purposes. The company also hinted that a managed cloud version is on the road map for later this year.

The new money should help Timescale continue fueling the growth and development of the product, especially as it builds out the commercial offering. Timescale, which was founded in 2015 in NYC, currently has 30 employees. With the new influx of cash, it expects to double that over the next year.

from Startups – TechCrunch https://tcrn.ch/2Scn2H6

#USA TrueLayer’s Payments API lets companies accept payments through Open Banking

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Open Banking and PSD2 — groundbreaking regulation from the U.K. and European Union, respectively — set out to fix what politicians and civil servants perceived as a malfunctioning financial services market, evidenced most prominently by the banking crisis in 2008. It is also closely linked to the EU’s privacy directive GDPR, which aims to ensure citizens are given better access and use of their own personal data.

Central to Open Banking is a requirement that banks open up the data they hold and offer an API to let customers optionally share financial information with third-party providers. The idea, amongst other more innovate use-cases, is to make it easier to shop around for financial services or to switch banks accounts entirely.

In addition, a second aspect of Open Banking, which arguably targets the Visa-Mastercard duopoly, stipulates that banks offer an API to let customers authorise payments directly from their bank account as an alternative to other types of payments, such as card payments or manual bank transfers.

Enter TrueLayer, the London startup that’s built a developer platform to make it easy for fintech and other adjacent companies, such as retailers, to access bank APIs and in turn ride the Open Banking and PSD2 gravy train. Today, the young company is launching a beta of its own Open Banking-based Payments API to enable businesses to start accepting payments through Open Banking.

By using the payment initiation process created by PSD2, TrueLayer says its new API offers a number of benefits over other payments options:

First is immediate settlement whereby cleared funds are received in just few minutes, as with any bank to bank transfer that uses “Faster Payments”.

Second is security, since the API requires active bank authentication before any money can leave the account. “This means high security and extremely low fraud rates,” claims TrueLayer. That’s not pure hyperbole: the nature of the payment initiation process, as stipulated by Open Banking, means the customer is required to sanction any payment request within their own bank’s app or website. The user journey (shown in the video below) goes something like, “hey my bank, please make this one-off transfer on my behalf to X”. The person or business receiving the payment never sees your bank details (or card details, for that matter).

Third is that it is cheaper as payments do not have the high fees of card transactions.

Lastly, the user experience is arguably more streamlined than some other payments options, including traditional bank transfers. For example, customers do not need to manually type in a business’ bank account number to transfer money to a business.

“Both businesses and consumers will benefit substantially, but I think the biggest winner will be merchants, application providers, and SMBs,” TrueLayer co-founder Francesco Simoneschi tells me when I ask him who the biggest benefactors will be.

“Faster Payments cuts the time it takes for a payment to come through from days to few seconds. This is a crucial factor for a lot of businesses where instant settlement and transaction risk are big concerns. Add to that the minimal costs involved to process a payment and our API will make a big difference in a short period of time. We think that many businesses will end up sharing these savings with their customers”.

Simoneschi won’t be drawn into saying who the biggest loser will be under the new payments directive, arguing that it isn’t a “zero-sum game”. “However, we do believe that payment initiation is disrupting the four-party model of the existing card networks,” he adds.

That’s because payment initiation is serviced via a direct relationship between the merchant and the customer’s bank. And although Simoneschi doesn’t think it will happen overnight, he believes that as merchants start to incentivise Open Banking payments for their customers, it is likely to quickly gain traction. One way for credit card companies to remain competitive, he says, is to embrace and enhance Open Banking payment initiation by adding services such as dispute management.

“It’s also worth noting that banks generate a substantial amount of revenue from the fees involved in credit and debit card transactions,” says Simoneschi. “These fees are paid for by merchants, and indirectly, by consumers. Reducing these transactions could sting the bottom line of some of the major banks. Another factor is how a few banks make money as the ‘acquirer bank’ — a bank that merchants use to receive and clear funds. PSD2 and Open Banking removes both parts of this equation, essentially making that role obsolete”.

Meanwhile, asked what use cases are initially best-suited to this new payment method, Simoneschi says the most obvious is any scenario where payment is normally done via manual bank transfer. For example, services that require you to top up your account, such as international money transfer apps, cryptocurrency exchanges (or even a pre-paid mobile phone account) are ideal candidates. He also thinks managing or facilitating B2B payments, such as payments requested by suppliers, is another extremely good fit.

Longterm, however, that’s barely scratching the surface. It’s not hard to see large merchants, such as Amazon, embracing Open Banking in a big way so that they bypass Visa and Mastercard as much as possible. For those merchants with less deep pockets, services like TrueLayer over time will likely help them do the same. In other words, the payments space is about to get interesting — again.

from Startups – TechCrunch https://tcrn.ch/2DEOxBd

#USA Wellness startup Hims enters the unicorn club with $100M investment

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Hims, known by many for its phallic New York subway advertisements, has raised an additional $100 million in venture capital funding on a pre-money valuation of $1 billion. The round was first reported by Recode and confirmed to TechCrunch by sources with knowledge of the deal.

A growth-stage investor has led the round, which is ongoing, with participation from existing investors. Our source declined to name the lead investor but did say it was a “super big fund” that isn’t SoftBank and that hasn’t previously invested in Hims.

Hims officially launched just over one year ago and has raised $197 million already, as well as incorporated a women’s wellness brand, Hers, to go alongside its flagship men’s wellness brand. The business sells sexual wellness products, skin care and hair loss treatments directly to consumers. In addition to erectile dysfunction medication, it offers the birth control pill to customers with prescriptions and Addyi, the only FDA-approved medication for women with hypoactive sexual desire disorder.

According to Recode, Hims spent months negotiating with investors, “with some of them balking at the valuation.” Meanwhile, our source says Hims passed on several viable terms sheets and had plenty of IVP — which led its last round — money in the bank ahead of their latest infusion.

$1 billion, a 2x increase from its previous valuation, is a hefty price tag for such an early-stage digital health startup. Then again, most valuations for venture-backed businesses are foolish.

San Francisco-based Hims is also backed by Forerunner Ventures, Founders Fund, Redpoint Ventures, SV Angel, 8VC, Maverick Capital and more.

 

from Startups – TechCrunch https://tcrn.ch/2G8SvDt

#USA Former Munchery employees sue company, blame CEO for shutdown

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The Munchery saga continues.

In a new class-action lawsuit, former Munchery facilities worker Joshua Philips is claiming the startup owes him and 250 other employees 60 days’ wages, citing The Worker Adjustment and Retraining Notification Act, a U.S. labor law that requires employers with an excess of 100 employees to give notice 60 days ahead of mass layoffs.

Munchery, a prepared meal delivery company headquartered in San Francisco, announced in an email to customers on January 21 that it would cease operations, effectively immediately. The abrupt shutdown not only came as a surprise to Munchery’s community of customers, but shocked vendors, many whom had been expecting payments from the business for several weeks. Munchery’s own employees were left in the dark, too, according to several former workers who spoke to TechCrunch about their debt and dissatisfaction with chief executive James Beriker.

Munchery ordered mass layoffs on January 21, per the lawsuit, the same day customers were notified the company would go out of business. In total, Philips is seeking equal to the sum of his and other affected employees’ “unpaid wages, salary, commissions, bonuses, accrued holiday pay, accrued vacation pay, pension and 401(k) contributions and other ERISA benefits, for 60 days, that would have been covered and paid under the then-applicable employee benefit plans.”

Munchery is deep in a pile of debt. The startup’s former vendors, which includes San Francisco-based Dandelion Chocolate and Three Babes Bakeshop, say they’re owed tens of thousands in overdue payments. Those businesses, and several other small vendors in San Francisco and Los Angeles that notified TechCrunch following the publication of this story, are still awaiting overdue payments, with one supplier claiming to be owed north of $100,000.

As of Monday morning, Munchery had yet to file for bankruptcy.

“They entered into a 14-month payment plan with us to cover nearly $150,000 in debt, but never had the intention of fulfilling their obligation,” an LA-based Munchery vendor, who asked not to be named, told TechCrunch. “The entire meal prep business is not sustainable on a grand scale like these companies envision.”

On top of its outstanding debts to vendors and facilities workers, Munchery also failed to send final paychecks to delivery drivers. Several Instagram messages provided to TechCrunch show a cluster of drivers in the San Francisco and Sacramento area are confused by the lack of communication from the venture-funded startup and are hopeful checks will arrive.

After arguing with Munchery employees, a delivery driver in Sacramento by the name of Sharon Howard said she finally received a “janky looking handwritten check” from the business on Monday and is hopeful it will clear.

“My co-workers up here in Sacramento have not received their final checks and are just um…waiting,” Howard wrote in an Instagram message shared with TechCrunch. “I sort of have the feeling that if they don’t speak up, they’re just gonna be forgotten about … It’s just not right to work with the expectation of getting paid and then just allow Munchery to turn a blind eye.”

Munchery chief executive officer James Beriker joined the startup in 2016

Munchery had raised $125 million in venture capital funding at a peak valuation of $300 million from Sherpa Capital, Menlo Ventures, Greycroft and more since its founding in 2010 by Tran and Conrad Chu. Aside from a small $5 million check, all that cash was deployed under the leadership of Tran, who struggled to improve Munchery’s margins and was eventually replaced by Beriker, the former CEO of Simply Hired.

Munchery, however, struggled under Beriker, too, and ultimately shut down its Los Angeles, Seattle and New York operations and laid off 30 percent of its workforce. A former Munchery employee, who asked not to be named, said Beriker’s poor leadership is to blame for the startup’s failure.

“The CEO was very disconnected to the business,” the person said in a text message. “We would see him maybe once every other week and only for 15 minutes — if that. The kitchen staff didn’t even know who he was when he came to the facility. In my time with the company, he was rarely truthful or transparent about the current state of the business and the future direction. Not to mention his very hefty salary that compared to that of a publicly traded Fortune 500 company.”

“My heart goes out to all of the big and small businesses that Munchery’s closure has and will affect,” the person added. “I am also hopeful that the staff who had zero advance knowledge of the closure will find employment quickly.”

Beriker has not responded to multiple requests for comment from TechCrunch. We’ve reached out to Munchery’s investors for additional detail surrounding the strange, sudden and silent shutdown.

Here’s a look at the full legal complaint:

from Startups – TechCrunch https://tcrn.ch/2FU15aa

#USA Sapphire Ventures bets big on esports and entertainment with new $115M fund

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Sapphire Ventures, formerly the corporate venture capital arm of SAP, has lassoed $115 million from new limited partners (LPs) to invest at the intersection of tech, sports, media and entertainment.

A majority of the LPs for the new fund, called Sapphire Sport, have ties to the sports industry, from City Football Group, which owns English Premier League team Manchester City, to Adidas, the owners of the Indiana Pacers, New York Jets, San Jose Sharks and Tampa Bay Lightning, among others.

The firm plans to do five to six investments per year, sized between $3 million and $7 million. So far, they’ve deployed capital to five startups: at-home fitness system Tonal, live soccer streaming platform mycujoo, digital sports network Overtime, ticketing and events platform Fevo and gaming studio Phoenix Labs. Sapphire began backing tech startups in 2008; in 2016, the firm closed on $1 billion for its third flagship venture fund.

Sapphire managing director and co-founder Doug Higgins is leading the effort alongside newly tapped partner Michael Spirito, who joined from 21st Century Fox, where he focused on business development and digital media for the Fox Sports-owned Yankees Entertainment and Sports (YES) Network, in September.

Higgins was an investment manager at Intel Capital for four years prior to co-launching Sapphire. Throughout his career, he’s managed the firm’s investments in LinkedIn, DocuSign, Square and more.

“We invest in anything that tech is disrupting,” Higgins told TechCrunch. “We were early investors in Fitbit, so we saw the beginning of digital fitness and how tech can impact the lives of anyone, not just high-performance athletes … We are also investors in Square, TicketFly and Paytm and what we’ve been seeing — the dream as a VC — is these massive markets in the sports, media and digital health world that are getting disrupted by tech.”

Sapphire is betting its traditional and well-established venture platform, coupled with the expertise of leading sports entities on board as LPs, will give it a competitive edge as it targets some of the best emerging sports tech companies.

“We see a lot of FOMO happening in this world, where everyone wants to have a play, but to make the best investment you need to have the widest perspective,” Higgins said. “So if you’re a team owner of a particular football team you are going to make better decisions if you are able to share perspectives with owners of other teams.”

“The best entrepreneurs, the ones we all want to invest in, there’s not a draft, they have to select you,” he added.

Investment in esports and gaming has skyrocketed, surpassing a total of $2.5 billion in VC funding in 2018. According to PitchBook, a handful of startups have already raised a total of $65 million in VC backing this year, including a $10.8 million financing for ReKTGlobal, a provider of esports infrastructure services.

“You can’t ignore the numbers on esports,” Higgins added. “They just continue to grow massively and people who have teenage kids, like myself, [those kids] want to grow up to be the next ninja, not the next Tom Brady .”

from Startups – TechCrunch https://tcrn.ch/2G5aGtP

#USA Kite raises $17M for its AI-driven code completion tool

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Kite, a San Francisco-based startup that uses machine learning to build what is essentially a very smart code-completion tool, today announced that it has raised a $17 million funding round. The round was led by Trinity Ventures, with personal participation from now-GitHub CEO Nat Friedman. In addition to the funding, Kite also today announced that its tools are now significantly smarter and that developers can run them locally on their machines, even if they don’t have an internet connection.

As Kite founder and CEO Adam Smith told me, the idea for Kite is based on the simple fact that a lot of programming is repetitive. “That’s why [developers] spend so much time on Stack Overflow. That’s why they spend so much time debugging really basic errors and looking up documentation, but not so much time looking at how the solution should work,” he said. “We thought we can use machine learning to fix that.”

Standard code completion tools often still use alphabetical sorting while Kite uses AI to infer what a developer is likely trying to do (though to be fair, the likes of IntelliSense and others are also starting to get smarter). In its first iteration, Kite, which sadly still only works for Python code right now, sorted its hints by popularity. Unsurprisingly, that was already more useful than alphabetical sorting and the right answer appeared in the top three results 37 percent of the time.

What’s interesting here is that if you can predict the next part of a line of code with high accuracy, you can start predicting a few more words ahead, too. And that’s exactly what Kite is starting to do now.

To do this, the team had to build its own machine learning models that worked well for code. As Smith told me, Kite first looked at using standard natural language processing (NLP) models, but it turns out that those don’t really work well for code, which has a different structure. As training data, Kite fed the system all the Python code on GitHub .

Looking ahead, what Smith really wants to achieve is what he calls ‘fully automated programming.’ “It’s that Star Trek vision of where you tell computers in a high-level language what to do,” he said. “If it’s ambiguous, the computer will ask questions.”

It’ll take a few more breakthroughs in AI to realize that vision, but for the time being, Kite’s tools are freely available and come with editor plugins for Atom, Sublime Text3, VS Code, Vim, PyCharm and IntelliJ. Currently, about 30,000 Python developers use its tools.

With today’s release, developers can also use these models locally, without the need for an Internet connection. That’s a sign of how efficient the models are, but as Smith also acknowledged, running the model locally means his company doesn’t have to manage a complex cloud infrastructure either. This should also make the tool more appealing to more developers — especially in larger corporations — given that the original tool would send all of your code to Kite’s servers (and in that context, it’s worth noting the company managed to create its own little scandal around some open source contributions that favored its auto-completion engine).

The company plans to use the new funding to build out the team, which mostly consists of engineers. It’ll also build out its product, with a special focus on supporting more languages.

As for its business model, it’s worth noting that Kite did test a subscription service last year, but as Smith argues, that was mostly to test if the company could monetize the service. “Now we want to optimize for growth,” he said and noted that the focus of the company’s monetization strategy will be on enterprise users. Indeed, that’s a common refrain I hear from startups that focus on developers. It’s very hard to sell subscriptions to individual developers, it seems, so most start to focus on enterprises sooner or later.

from Startups – TechCrunch https://tcrn.ch/2DE6sHX

#USA China’s social credit system won’t tell you what you can do right

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For the past few years, China has been rolling out a Black Mirror Harry Potter-esque social rating policy known as the Social Credit System (SCS). Far from just a credit score in the financial sense, an SCS score can determine whether a person can buy business class tickets on trains (or take the train at all) or have access to flights. Apps are rumored to exist that would tell users whether they are standing near someone with a debt listed in the system, so … they can walk away I guess.

This is a massive undertaking, and researchers are finally starting to collect good data on the system’s operation, such as a MERICS report looking at the implementation of this complex system, which involves companies and all levels of the Chinese government. Westerners have also increasingly explored the generally positive reception of the system by Chinese citizens, which would seem at odds with typical desires for privacy.

Yet, one of the biggest and most obvious open questions is what exactly will get you rewarded or punished by the SCS? Now, we are finally starting to get answers.

In a new paper that will be presented this week at the ACM FAT* Conference on algorithmic transparency, a group of researchers investigated how positive and negative points were assessed by downloading a large corpus of hundreds of thousands of entries from the Beijing SCS website and analyzing it with content analysis machine learning tools.

They found that Beijing was remarkably clear about what will get you punished, but vague about what will get you positive points. For instance, the vast majority of the blacklist was made up by people who had failed to pay their debts, or who had committed a traffic violation. Meanwhile, the people on the redlist (the positive list) were there because they were, say, great volunteers, but with no criteria on how to get that status or why they were listed at all.

“It’s very difficult to pinpoint the exact degree of transparency,” of SCS said Severin Engelmann, one of the lead researchers based at the Technical University of Munich. Far from being just an experimental startup, SCS is already quite advanced. “Blacklisting and redlisting are already in place, and they clearly indicate what behavior is bad … but not what behavior is actually good,” he said.

Even more interesting, there are more companies on the blacklist and redlist than there are individuals within the Beijing corpus, indicating that while the government is certainly concerned about citizens, it’s bringing its social control mechanism onto companies perhaps more aggressively.

Jens Grossklags, another of the researchers, noted that this level of transparency — while inconsistent — was unusual in the West. “It is really fascinating from a data science perspective to see how much information is being made available not just to individuals but to the general public,” he said. He noted that public shaming has been common with the Chinese system, while Western consumers have a hard time accessing their own scores let alone the scores of others.

The study is one of the first to look at the actual implementation of SCS and reverse engineer its algorithm, and the researchers are potentially following up by investigating regional variations and further changes to the system.

TechCrunch is experimenting with new content forms. This is a rough draft of something new – provide your feedback directly to the author (Danny at danny@techcrunch.com) if you like or hate something here.

Share your feedback on your startup’s attorney

My colleague Eric Eldon and I are reaching out to startup founders and execs about their experiences with their attorneys. Our goal is to identify the leading lights of the industry and help spark discussions around best practices. If you have an attorney you thought did a fantastic job for your startup, let us know using this short Google Forms survey and also spread the word. We will share the results and more in the coming weeks.

Stray Thoughts (aka, what I am reading)

Short summaries and analysis of important news stories

Hustling to nothing

Erin Griffith has a great piece on the increasing pervasiveness of hustle culture. This is part of a long-running debate in Silicon Valley between the work-your-ass-off crowd and the productivity-peaks-at-35-hours crowd. The answer in my mind is that we should see work in phases — running at 100 MPH all the time is most definitely not sustainable, but neither frankly is working a very stable number of hours per week. The vagaries of life and work mean that we need to surge and recede our efforts as dictated, and always track our own health.

Nvidia’s troubles continue

We’ve talked a lot about Nvidia over the past few months (Part 1, Part 2, Part 3). Well, the bad news train just continues. As my colleague Romain Dillet reports, Nvidia is cutting its revenue outlook, and now the stock is falling again (another 14% as I write this). It cites lowered demand particularly from China, which is experiencing a major slowdown in its economy.

Can Chinese startups subsidize customers forever?

The Financial Times asks an important question about the “China model” of startups: should founders heavily subsidize customers in order to buy market share and fight competitors? They point to bike sharing startup Ofo’s collapse, although I would point to the expensive rise of Luckin Coffee as perhaps the latest example. It’s a lesson that Munchery’s investors also have had to learn: at the end of the day, those unit economics better turn positive if a company is to survive.

What’s next

  • More work on societal resilience

This newsletter is written with the assistance of Arman Tabatabai from New York

from Startups – TechCrunch https://tcrn.ch/2SboKIB

#USA Lack of transparency in healthcare startups risks another Theranos implosion

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Are more Theranos -style scandals looming for investors in healthcare startups?

A team of researchers associated with the Meta-Research Innovation Center at Stanford thinks so. They’ve published a paper warning investors in life sciences startups that a systemic lack of transparency exists in their portfolio companies — creating the possibility for more multi-billion-dollar implosions and scandals like the one that toppled Theranos and its charismatic founder, Elizabeth Holmes.

Indeed, one of the study’s authors, Dr. John Ioannidis, the co-director of the Meta-Research Innovation Center at Stanford and director of the University’s PhD program in Epidemiology and Clinical Research, was  among the first people to identify the risks associated with Theranos and its “stealth research.”

Now Dr. Ioannidis and his co-authors, Ioana A. Cristea and Eli M. Cahan, have published a study surveying the publicly available research from the largest privately held companies in the healthcare space, and found them lacking. 

Most of the highest-valued startups in healthcare have not published any significant scientific literature, the study found. Nearly half of the publications from companies worth more than $1 billion came from only two startups — 23andMe and Adaptive Biotechnologies, according to the paper.

“Many years ago I was the first person to say that Theranos had a problem,” says Ioannidis. “The problem that I had then was that Theranos did not have any peer-reviewed evidence to show.”

In an interview and in their paper, Ioannidis and Cahan warn that investors have overlooked systemic problems created by the lack of transparency among healthcare startups.

They write:

It would be tempting to dismiss the Theranos case as just one rotten apple. However, we worry that the focus on fraud puts aside a more fundamental concern. Fraud is making waves in the news, but stealth research may have a more detrimental impact.

According to the study’s findings, more than half of the healthcare startups that are worth more than $1 billion have published no highly cited papers at all. For companies that were acquired or are publicly traded that number is around 40 percent.

In all, healthcare startups that are currently valued at more than $1 billion published 425 Pubmed papers. And of those papers only 34 (8 percent, including two reviews) were highly cited. For companies with valuations of more than $1 billion that had been acquired or are publicly traded on stock exchanges, the researchers counted 413 papers, of which 47 (11 percent, including nine reviews) were highly cited.

Digging deeper into some of the companies that had high valuations but little or no published research revealed scores of operational and technological issues for the researchers.

For instance, StemCentrx, which was bought for $10.2 billion in 2016 by AbbVie, had published 16 papers — and only one highly cited paper. Since the acquisition, the Food and Drug Administration had imposed a delay on the readout of the company’s phase II trial for its Rova T targeted antibody drug for cancer treatment. In December, a Phase III trial for Rova T as a second-line treatment for patients with advanced small cell lung cancer was halted because the treatment wasn’t working, according to a report in Targeted Oncology.

Acerta Pharma, another healthcare-focused startup focused on cancer treatments, was bought by AstraZeneca for $7.3 billion. That company published nine articles and had one highly cited paper for a very early study of a potential treatment for relapsed chronic lymphocytic leukemia. Acerta received accelerated approval for a drug called acalabrutinib, which treats a rare form of lymphoma called mantle cell lymphoma. Two years ago, AstraZeneca had to retract data and admit that Acerta falsified preclinical data for its drug.

Then there’s Intarcia, the developer of a device for diabetes treatment that’s worth $5.5 billion. That company had its device rejected by the FDA and was forced to lay off staff and halt a couple of later-stage trials. It had only published six papers — none of them very highly cited.

Ultimately, the researchers concluded that highly valued healthcare startups don’t contribute to published research and that the valuation of these companies by investors is divorced from any externally validated data.

For the researchers (and for investors) this should present a problem.

“Many unicorns may be overvalued [21] and subject to unrealistic scientific expectations,” the study’s authors write. And they reject the argument that simply applying for — and receiving — patents is enough to prove that a technology in the healthcare space has been thoroughly vetted. “[Patents] do not offer the same level of documentation as peer-reviewed articles. For example, Theranos had over 100 patents [1], but these were unable to supplant the vacuum in their evidence,” the researchers wrote. 

Even if companies want to protect their technology, there are still ways for them to be more transparent about the results or benefits of their technology. The authors acknowledge that publishing isn’t the primary mission of startups. They can, however publish a few high-value articles, secure their technology through patents and then work with researchers, universities or hospitals to validate the technology and have those organizations publish results of the tests, the authors argue.

As the authors conclude:

Start-ups are key purveyors of innovation and disruption. Consequently, holding them to a minimal standard of evaluation from the scientific community is crucial. Participation in peer review, with all its limitations, is the best way we have to uphold this standard. We are not arguing that start-ups should divert excessive resources to having peer-reviewed papers. However, when their products are destined to affect patient health, they should neither be solely doing marketing. Confidential data sharing with potential investors or regulators cannot replace more open scrutiny by the scientific community.

 

from Startups – TechCrunch https://tcrn.ch/2TjoHIe

#USA China’s social credit system won’t tell you what you can do right

//

For the past few years, China has been rolling out a Black Mirror Harry Potter-esque social rating policy known as the Social Credit System (SCS). Far from just a credit score in the financial sense, an SCS score can determine whether a person can buy business class tickets on trains (or take the train at all) or have access to flights. Apps are rumored to exist that would tell users whether they are standing near someone with a debt listed in the system, so … they can walk away I guess.

This is a massive undertaking, and researchers are finally starting to collect good data on the system’s operation, such as a MERICS report looking at the implementation of this complex system, which involves companies and all levels of the Chinese government. Westerners have also increasingly explored the generally positive reception of the system by Chinese citizens, which would seem at odds with typical desires for privacy.

Yet, one of the biggest and most obvious open questions is what exactly will get you rewarded or punished by the SCS? Now, we are finally starting to get answers.

In a new paper that will be presented this week at the ACM FAT* Conference on algorithmic transparency, a group of researchers investigated how positive and negative points were assessed by downloading a large corpus of hundreds of thousands of entries from the Beijing SCS website and analyzing it with content analysis machine learning tools.

They found that Beijing was remarkably clear about what will get you punished, but vague about what will get you positive points. For instance, the vast majority of the blacklist was made up by people who had failed to pay their debts, or who had committed a traffic violation. Meanwhile, the people on the redlist (the positive list) were there because they were, say, great volunteers, but with no criteria on how to get that status or why they were listed at all.

“It’s very difficult to pinpoint the exact degree of transparency,” of SCS said Severin Engelmann, one of the lead researchers based at the Technical University of Munich. Far from being just an experimental startup, SCS is already quite advanced. “Blacklisting and redlisting are already in place, and they clearly indicate what behavior is bad … but not what behavior is actually good,” he said.

Even more interesting, there are more companies on the blacklist and redlist than there are individuals within the Beijing corpus, indicating that while the government is certainly concerned about citizens, it’s bringing its social control mechanism onto companies perhaps more aggressively.

Jens Grossklags, another of the researchers, noted that this level of transparency — while inconsistent — was unusual in the West. “It is really fascinating from a data science perspective to see how much information is being made available not just to individuals but to the general public,” he said. He noted that public shaming has been common with the Chinese system, while Western consumers have a hard time accessing their own scores let alone the scores of others.

The study is one of the first to look at the actual implementation of SCS and reverse engineer its algorithm, and the researchers are potentially following up by investigating regional variations and further changes to the system.

TechCrunch is experimenting with new content forms. This is a rough draft of something new – provide your feedback directly to the author (Danny at danny@techcrunch.com) if you like or hate something here.

Share your feedback on your startup’s attorney

My colleague Eric Eldon and I are reaching out to startup founders and execs about their experiences with their attorneys. Our goal is to identify the leading lights of the industry and help spark discussions around best practices. If you have an attorney you thought did a fantastic job for your startup, let us know using this short Google Forms survey and also spread the word. We will share the results and more in the coming weeks.

Stray Thoughts (aka, what I am reading)

Short summaries and analysis of important news stories

Hustling to nothing

Erin Griffith has a great piece on the increasing pervasiveness of hustle culture. This is part of a long-running debate in Silicon Valley between the work-your-ass-off crowd and the productivity-peaks-at-35-hours crowd. The answer in my mind is that we should see work in phases — running at 100 MPH all the time is most definitely not sustainable, but neither frankly is working a very stable number of hours per week. The vagaries of life and work mean that we need to surge and recede our efforts as dictated, and always track our own health.

Nvidia’s troubles continue

We’ve talked a lot about Nvidia over the past few months (Part 1, Part 2, Part 3). Well, the bad news train just continues. As my colleague Romain Dillet reports, Nvidia is cutting its revenue outlook, and now the stock is falling again (another 14% as I write this). It cites lowered demand particularly from China, which is experiencing a major slowdown in its economy.

Can Chinese startups subsidize customers forever?

The Financial Times asks an important question about the “China model” of startups: should founders heavily subsidize customers in order to buy market share and fight competitors? They point to bike sharing startup Ofo’s collapse, although I would point to the expensive rise of Luckin Coffee as perhaps the latest example. It’s a lesson that Munchery’s investors also have had to learn: at the end of the day, those unit economics better turn positive if a company is to survive.

What’s next

  • More work on societal resilience

This newsletter is written with the assistance of Arman Tabatabai from New York

from Startups – TechCrunch https://tcrn.ch/2SboKIB

#USA The new Parsley Health Center in NYC doesn’t feel like a doctor’s office

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Parsley Health has just opened up a new, fully redesigned space on Fifth Avenue in New York City, marking the first true Parsley Health Center.

Since launch, the startup has been operating out of clinics in New York, San Francisco and Los Angeles. But TechCrunch got the chance to check out Parsley’s new Fifth Ave location, which marks the company’s first space designed from the ground up as Parsley Health.

Founded by Dr. Robin Berzin, Parsley Health is a healthcare membership, where customers are offered a holistic approach to their health by a team of doctors and health coaches, complete with 24/7 unlimited messaging.

The idea stemmed from the troublesome reality that the average American spends less than 20 minutes a year with their doctor, who more often than not treat symptoms instead of the root problem.

Parsley members spend around four hours/yr with medical professionals, including five doctor visits a year and five health coach visits. Plus, Parsley offers 24/7 communication with your doctor and health coach. The hope is that Parsley doctors can better diagnose and treat their patients’ issues if they have the time to get the full story. Plus, Parsley doctors have the benefit of advanced biomarker testing alongside their focus on functional medicine, where root issues are prioritized for treatment rather than symptoms.

Part of giving the highest quality treatment is creating an open relationship between doctor and patient. That, in many ways, can be influenced by the physical space.

The new Parsley Health Center takes into account the principles of biophilic design. In other words, the space is designed specifically to make people feel healthier and better. The lighting, for example, is built to mimic natural light by using ribbed glass partition systems in the smaller rooms of the space. The space is also full of plants, as being in connection with nature reduces stress and improves mood.

The company even paid attention to the details of designing a main hallway where the halls that sprawl off of the main corridor are somewhat hidden by overhanging walls. This pattern, of visually implying a mystery waits around the corner, is supposed to provoke a strong pleasure response.

Beyond the design itself, Parsley also took into account the look and feel of the waiting room.

Rather than a sterile room with old magazines and no light, the Parsley waiting room is more of a communal living room, with plenty of couches and a kitchen, complete with draught kombucha and healthy snacks for purchase.

The hope is that Parsley can use this room for community events around learning how to optimize health across all parts of life, including food, sleep, and behavior.

Doctor’s offices and exam rooms are rethought to ensure a more comfortable relationship between doctor and patient. There are no desks that separate patient from doctor, instead featuring a couch with a small side table to write on.

Observation tables have been redesigned to fit in with the room instead of standing out like a giant piece of ‘medical equipment’. Doctors’ instruments all fit into a small set of drawers off to the side.

Even the lab is built adjacent to a restroom where patients can pass their specimen through a small compartment in the wall instead of walking it through the hallways.

In 2017, Parsley raised $10 million led by FirstMark Capital, with participation from Amplo, Trail Mix Ventures, Combine and The Chernin Group. Individual investors such as Dr. Mark Hyman, M.D., director of the Cleveland Clinic Center for Functional Medicine; Nat Turner, CEO of Flatiron Health; Neil Parikh, co-founder of Casper; and Dave Gilboa, co-founder of Warby Parker, also invested in the round.

Membership to Parsley costs $150/month.

from Startups – TechCrunch https://tcrn.ch/2CMzCTH