#UK Zafgen reports second death in key drug study

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NEW YORK (AP) — Zafgen Inc. on Wednesday reported a second patient death in an ongoing study of its potential treatment for a rare genetic disorder linked to obesity.

The Boston-based company’s shares plunged 60 percent in midday trading Wednesday.

The biotechnology company said the patient died from a blockage in an artery in the lung, or blood clots, in the late-stage study of beloranib. It reported a previous death in October in the same study, but the cause is unknown.

The Food and Drug Administration placed a partial hold on the study following the first reported death.

Beloranib is the company’s lead drug candidate and is aimed at treating the rare genetic disorder called Prader Willi syndrome. The condition has multiple symptoms and is linked to obesity.

The company said it is in discussions with the FDA to determine next steps for the program. Results of from another portion of the study are expected during the first quarter.

Zafgen shares dropped $9.59, or 60.1 percent, to $6.43 in midday trading Wednesday. Its shares are down almost 80 percent this the year.

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#UK The unofficial Goldman Sachs holiday gift guide for 2015

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Cobalt_48It’s that time of year again — when children everywhere discover that Santa Claus loves rich kids more.

This year, the Neiman Marcus “fantasy gifts” list features a Ford Mustang, apparently for all the big lotto scratch-off winners out there. And Gwyneth Paltrow’s “ridiculous but awesome” gift guide includes a nightstand condom dispenser and a $244 toothpaste squeezer. Gross.

It shouldn’t be that hard to find the perfect gift, even for the man who has everything. Since we had some success with our timeless gift ideas in previous years (2013 and 2014), here’s the 2015 edition of the @GSElevator Holiday Gift guide.

John LeFevre is the creator of @GSElevator on Twitter and the author of the New York Times best-selling book “Straight to Hell: True Tales of Deviance, Debauchery, and Billion-Dollar Deals.”

He thinks he’s James Bond

The Cobalt Co50 Valkyrie ($750,000) is a fighter jet-inspired private plane, with a 320-degree view and enough room for four passengers and their golf bags. It’s also the fastest piston aircraft on the market. Since the plane won’t deliver in time for the holidays, Bonham’s is having a motorcar auction on December 6 that includes a 1964 Aston Martin DB5 ($600,000) and a 1955 Mercedes-Benz SL Gullwing Coupé ($1,500,000).

He loves nature but doesn’t get out much

A bonsai tree is a work of art, sometimes hundreds of years in the making. The delicate balance of managing air, water, sun, temperature, nutrients, and pruning is both rewarding and therapeutic. Raise the stakes with this 200-year-old Elm Bonsai in Zisha Pot ($28,000). Make sure you also throw in this beautiful Japanese bonsai tool kit ($75).

He talks about being charitable

Most guys would never think to buy themselves a silk, beech wood, and lacquered maple umbrella. The best way I know to acquire a fancy umbrella is to bring a cheap one to church and then upgrade on the way out. But it can be a great and practical fashion accessory. With this gorgeous Mr Stanford umbrella ($225), 70% of the retail price will be donated to the Elton John AIDS Foundation.

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#UK US space station delivery on tap after 8-month stoppage

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CAPE CANAVERAL, Fla. (AP) — NASA hopes to resume commercial shipments this week to the International Space Station, following months of frustrating delay.

The last successful U.S. supply run was in April.

An unmanned Atlas V (five) rocket arrived at its Cape Canaveral, Florida, launch pad Wednesday. It’s due to lift off Thursday with 7,400 pounds of station supplies. Shipper Orbital ATK considers it an early Christmas present for the crew.

The Atlas is a stand-in for Orbital’s Antares rocket, still grounded following a 2014 launch explosion. Both the rocket and the company’s cargo ship were destroyed, and the Virginia launch pad was damaged. Orbital plans another shipment via an Atlas in March, followed by the return of Antares in May.

NASA’s other contracted shipper, SpaceX, has been grounded since a failed launch in June.

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#UK Zuckerberg pledge follows ‘Buffett challenge’

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Microsoft co-founder and chairman Bill Gates (L) and Melinda Gates (C) listen as US investment guru Warren Buffett discusses his

Washington (AFP) – Mark Zuckerberg’s pledge to give away his Facebook holdings is the latest philanthropic initiative by America’s wealthy, and follows a challenge by billionaire Warren Buffett to the world’s other billionaires.

The announcement by the Facebook founder and his wife Priscilla Chan to donate 99 percent of their Facebook shares, or some $45 billion, to charitable causes during their lifetime far exceeds the challenge by Buffett, who urged the wealthy to give away at least half their fortunes.

The “Giving Pledge” was launched in 2010 by Buffett and Microsoft co-founder Bill Gates, who have been among the world’s richest individuals over the past decade.

The two business icons had called on the wealthy to pledge to charity at least half their assets during their lifetimes or upon their deaths. They quickly enlisted a small group that included CNN founder Ted Turner, then-New York mayor Michael Bloomberg, Oracle co-founder Larry Ellison and Hollywood director George Lucas.

In the group’s latest update in June, the list had grown to 137 individuals and families. Those who signed the pledge come from 14 countries: Australia, Brazil, Germany, India, Indonesia, Malaysia, Russia, South Africa, Taiwan, Turkey, Ukraine, United Arab Emirates, Britain and United States. 

“When we started the Giving Pledge five years ago, we had no idea we’d get this many people to come together. It has really grown, first in the US but more recently all over the world,” said Gates in a statement.

“We hope to intensify philanthropy and encourage people to get started younger. It’s exciting to see people becoming bolder and more thoughtful in their giving. This is about building on a wonderful tradition of philanthropy that will ultimately help the world become a much better place.”

The group says it “hopes to help shift the social norms of philanthropy toward giving more, giving sooner and giving smart.”

Some of the charities designated by the wealthy seek to advance medical research, improve education, support children in underserved schools and neighborhoods, and promote global development and economic opportunities in Africa.

Gates and his wife have created their own foundation with an endowment of more than $41 billion, which has funded projects in the United States, Asia, Africa, Latin America, the Middle East and Europe.

While the giving initiative has gained momentum, especially among tech billionaires, the tradition of philanthropy has a long history in the United States.

A group of wealthy industrialists who made fortunes in the late 19th and early 20th century — denigrated by some as “robber barons” — became known for their philanthropy as well. These included Andrew Carnegie, John D. Rockefeller, Cornelius Vanderbilt and Henry Ford.

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#UK 13 dream gifts for insanely wealthy science and technology fanatics

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Triton Sub 3300/3

Most of us have limits on what we spend for Christmas.

But in a world with no limits, what would you spring for?

Perhaps a trip to space, where you and your family could gaze down at the Earth? A diving session to watch great white sharks rip apart dinner? Or your own hoverboard, for cruising across your own specially designed track?

We’ve picked some of our favorite super-size gift ideas for science and technology fans (one can dream, right?).

Whether you’re interested in exploring the ocean depths or getting your hands on a technology out of a sci-fi movie, there’s something here for everyone — with extraordinarily deep pockets.

1. Zoom around with this giant jetpack.

If you’re tired of planes, trains, and cars, then the Martin Jetpack might be a good choice.

It’s a little bulkier than the jetpacks we see in movies, but it really works!

A V4 engine and ducted fans (sort of like a helicopter) power the device, which can fly up to 30 minutes and reach a maximum altitude of 3,280 feet.

Right now the company is marketing the jetpack to the military and to rescue operations from extremely tall buildings.

Price: $150,000

2. Take a trip to the International Space Station.

Vacations make great gifts, but why not pick somewhere a little more exotic than the Bahamas — perhaps the International Space Station?

You can book a trip through Space Adventures. The exact price depends on what time of year you want to go and how long you want to stay. 

Price: A 10-day stay will cost you $52 million, but spacewalks aren’t included — those cost an additional $15 million each.

3. Float up to the edge of space

If you’re not quite ready for space, then the private space tourism company World View will float you 20 miles above the Earth in a capsule carried by a balloon. 

At that height it’s still possible to experience the “overview effect” — a cognitive shift experienced by some astronauts when they catch a glimpse of the Earth from space. The experience leaves people feeling deeply connected to the world and fills them with a desire to protect it and change it for the better.

World View is planning on ferrying the first passengers to the edge of space at the end of 2016, so you might want to save this one for next year’s gift list.

Price: $75,000

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#UK DRAGHI’S BAZOOKA: What to expect from the ECB’s massive meeting tomorrow

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Draghi ECB Mario

The European Central Bank meets on Thursday, and analysts are expecting a major announcement.

In late October, ECB President Mario Draghi dropped a major hint that there was going to be more monetary easing in the very near future — either in the form of further interest rate cuts, or some form of boost to the quantitative easing programme.

In a speech this November, Draghi doubled down, saying that the ECB “will do what we must to raise inflation as quickly as possible,” a phrase a bit like his “whatever it takes” speech in mid-2012, which was credited with bringing an end to the euro crisis.

The meeting concludes at 12:45 p.m. GMT (7:45 a.m. ET), when we’ll get any announcement of changes in interest rates, and the crucial press conference starts 45 minutes later.

Here’s how things stand at the moment:

  • The last ECB interest rate cut (the 11th since November 2008) came in September 2014, when the deposit rate was clipped from -0.1% to -0.2%. Two other policy rates — the fixed rate and the marginal lending facility — were cut to 0.05% and 0.30% respectively.
  • In January 2015, the ECB announced a QE programme. It entailed buying €60 billion ($63.41 billion, £42.46 billion) of investment-grade government debt and some other securities it was already buying in smaller schemes, per month.
  • This was meant to last until September 2016, or until the central bank saw a meaningful pick-up in inflation. Soon after, the eurozone recovery reached a recent peak, hitting 0.5% GDP growth in Q1. It’s since slowed to 0.4% in Q2 and 0.3% in Q3.
  • There has been very little pick-up in inflation over the period since QE was announced. Because of tumbling oil prices, consumer prices have risen by basically nothing on aggregate this year. Core inflation, which strips out volatile prices like fuel, rose by 0.9% in the year to November, about half of what the ECB would like.

And here’s what’s on the table in the upcoming meeting:

  • The ECB could cut rates. Draghi previously suggested the September 2014 cut was the lowest the ECB could go, but revised his view in October, saying that other central banks had managed to cut rates further into negative territory.
  • They could boost QE. This could mean a number of things. The ECB could extend the universe of bonds it’s willing to purchase, into things like municipal bonds. It could extend the suggested end of the programme, or it could increase the amount purchased monthly.
  • They could do both. This would be the both barrels approach — doing both would also loosen up the limits on how much QE can be done. Currently, the ECB can’t buy bonds yielding less than the deposit rate (-0.2%). With an increasing weight of EU sovereign bonds carrying negative yields, that would widen the scope that could be bought.

The one thing that’s clear is that it has to be big. Markets have now priced in a move from the ECB, and if they’re disappointed it’ll likely mean a stronger euro and a slump for European equities, at least in the short term. 

What’s interesting is the lack of opposition that Draghi’s comments have prompted. Since October, resident Hawks like Bundesbank chief Jens Weidmann have done little more than make lukewarm comments opposing monetary easing in general.

Over at the FT, Gavyn Davies referred to the ECB as having “the zeal of a convert.” It was years behind other major central banks in its adoption of unconventional measures like QE, but now that it’s there, it seems to be far less conservative about its approach.

The combination of the impending easing from the ECB and the impending rate hike from the Federal Reserve has analysts expecting the euro to fall to parity with the dollar for the first time in more than a decade — analysts at Deutsche Bank, Capital Economics, Macquarie, Citi, Goldman Sachs, Credit Suisse are all expecting a 1:1 exchange rate between the euro and dollar to be reached in the next few months.

ECB eurusd

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#UK CSX cuts outlook, again, as appetite for coal fades

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OMAHA, Neb. (AP) — For the second time this year, CSX railroad has cut its annual outlook as the nation’s appetite for coal deteriorates further.

Chief Financial Officer Frank Lonegro said Wednesday that CSX now expects earnings-per-share growth of about 3 percent in 2015.

That forecast includes a property sale that will add 5 cents per share to CSX’s fourth-quarter profit.

CSX had earlier predicted for profit growth-per-share in the mid-single digits. The Jacksonville, Florida, railroad cut its outlook in September, also because of weak coal demand.

Lonegro says domestic coal shipments declined more than expected in the fourth quarter.

CSX shares fell almost 3 percent to trade for $27.85. Shares have now fallen 23 percent this year and the CSX report appeared to pull down shares of other railroads as well Wednesday.

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#UK Capitol Hill Buzz: Harry Reid has strong words for GOP

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Senate Minority Leader Harry Reid of Nev. expresses his frustration with the Republican leadership during a news conference following a meeting on Capitol Hill in Washington, Tuesday, Dec. 1, 2015.    (AP Photo/J. Scott Applewhite)

WASHINGTON (AP) — Senate Democratic Leader Harry Reid is heading into retirement next year. Before he goes he has some strong words for Republicans.

In a floor speech Wednesday, the Nevada lawmaker accused Republicans of “running on a platform of hate.” He said that the party and its candidates “demagogue women” and direct “insults and slander” at Muslim-Americans, immigrants, and supporters of the Black Lives Matter movement.

Reid directed his criticism at the party in general and at the GOP’s presidential candidates, citing comments by Donald Trump, Ted Cruz, Marco Rubio, Ben Carson and others to accuse them of disparaging immigrants and minorities.

“The simple fact is that Republicans are running on a platform of hate,” Reid charged. “Every Republican who fails to speak out against the hateful, dangerous rhetoric being spewed by their party is complicit. For the moral character of our nation we must demand that Republicans return to the values on which our country was founded.”

An occasional look at what Capitol Hill is talking about

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#UK I became a millionaire in 10 years without picking stocks, and here are the questions people ask

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rootofgood monte alban mexico

Hi, it’s Justin from Root of Good.

I wanted to respond to a few of the frequent questions and comments that appeared in response to my article on how I became a millionaire in 10 years without winning the lottery or picking stocks.

SEE ALSO: How I became a millionaire in 10 years without winning the lottery or picking stocks

Savings and expenses

Lots of people called BS on our savings rate. That’s understandable because it’s shockingly high.

But it really comes down to math. There’s an irrefutable mathematical relationship between income, savings, and expenses.

Income goes toward three things: expenses, taxes, and savings. Stated mathematically, Income = Expenses + Taxes + Savings.

Rearrange the formula and you get: Savings = Income – Expenses – Taxes. In other words, you can save all of your income that doesn’t go toward living expenses and taxes. Limit expenses and taxes and you increase savings.

We saved a lot by living frugally in Raleigh, North Carolina (a low to moderate cost of living area) and having decent incomes. The biggest expenses for almost everyone are housing, transportation, and food. We focused on saving money on those areas.

We still drive the cars we bought brand new 15 years ago while in college (three kids can fit in the back of a Honda Accord). We never upgraded from our starter home. And we don’t go out to eat very often, preferring to cook awesome meals at home instead.

It’s nothing radical at all, and something that pretty much anyone can implement in their own lives if they want to. Saving our raises and bonuses instead of increasing our standard of living also increased the amount we were able to save each year.

While working, we spent around $24,000 per year on core expenses (not including mortgage). Right now, we have a budget of $32,400 per year in early retirement. This might seem low for a family of five, but remember our house is paid off. During our ten years of wealth-building covered in this article, our mortgage varied from a monthly payment of $500 up to $1,250 as we refinanced to shorter loan terms.

How can you save $75,000 on a $95,000 salary?

Some commented that the annual salaries don’t make sense compared to the “Additions to Portfolio” shown in the table. Take 2006, for example. We made $95,000 yet managed to add $75,000 to the portfolio. Not included in our $95,000 combined salaries were 401k matches of maybe $8,000 (records are fuzzy here) plus another $8,000 to $10,000 in profit sharing into my Employee Stock Ownership Plan. I treated the 401k matches and ESOP contributions as “additions to portfolio” but they aren’t included in our salaries since I didn’t want to give an inflated sense of how much we actually made at pretty ordinary jobs (for those with college degrees in engineering or business).

In 2006, our combined “grossed up” salaries including the 401k matches and ESOP contributions were closer to $115,000 (again, my records are fuzzy beyond the straight salaries). This means we spent about $40,000 between payroll taxes, income taxes, and living expenses. $40,000 is a lot more realistic for all that compared to $20,000 if you just glance at the table!

Nationally, the median household income is somewhere around $50,000 to $60,000 per year. In other words, we were living a lifestyle just a little below median while enjoying salaries and benefits significantly more than the median (but still comfortably middle class ,I would argue).

Regarding taxes, we paid very little due to some hard core tax planning efforts, three kids, and plain old luck. In the last year that both of us worked, our combined incomes were just under $150,000 yet we only paid $150 in federal income tax. We maxed out 401k’s, IRAs, and an HSA. As a government employee, I also had access to a 457 and a pension plan so I was able to contribute and deduct another $20,000 beyond what most employees can.

If you think what we did is impossible, just remember that North Carolina is still accepting new immigrants from other states, and the state government continues to hire people all the time. However, I would suggest working for a different employer if top pay is a priority!

Does our lifestyle suck?

One Business Insider commenter, Nutjobmoron, said: “Also, what is his life of ‘retirement’ like now. He can only afford to get up, sit on the couch and eat pasta. No golf, no boating, no beemer and no expensive steak dinners.”

Another commenter answered Nutjobmoron very eloquently:

The fact that he doesn’t have a boat, or go golfing or drive a beemer is the exact reason he is able to do this. Might not be the life you want, but it is the life he has and he seems super happy with it.

But you’re right — dude gets to spend time with his family and travel whenever he wants, doesn’t even have to go to work every day. Such a loser.

That sums it up well. We didn’t spend money on all that stuff which allowed us to save tons toward our financial independence.

We don’t own a boat and probably never will. Preferring to rent instead of own, we do go on a cruise (a very big boat) once or twice per year. The past two years we’ve taken multi-week international vacations including a two and a half week road trip to Canada last year and a seven week trip to Mexico this year. Leaving the couch and my plate of pasta was required for all of these trips. We did eat quite a bit of steak dinners while on these trips.

I acknowledge it’s impossible to dine at fancy steakhouses every night, own a yacht, a fleet of late model German imports, and a mansion while living on $30,000 to $40,000 per year. But that lifestyle was never our goal and isn’t something we would get a lot of value out of anyway.

Our 15-year-old Hondas run very well. Our house is perfect for our family of five and in a convenient location. We budget enough to allow some pretty crazy travel (considering that we have three kids). We also enjoy the freedom of not needing to work.

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#UK 26 time-management tricks I wish I’d known at 20

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time management slide

Most people learn time management the hard way: by trial and error.

Étienne Garbugli, a Montreal-based product and marketing consultant and the author of “Lean B2B: Build Products Businesses Want,” distilled the lessons he wishes he’d known when he was 20.

He created the following presentation, posted to SlideShare, which we’ve shared here with his permission.

This is an update of an article originally posted by Max Nisen.

SEE ALSO: 6 subtle things highly productive people do every day

DON’T MISS: 25 daily habits that will make you smarter

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